Mary Case started her career as a registrar focused on collections-rich museums, including the Mercer Museum (Doylestown, PA), the Strong Museum (Rochester NY), and the Smithsonian Institution (Washington, DC), where she responsible for access and accountability of collections ranging from the Ruby Slippers, four million ticks, and one of seven known red diamonds. Additionally, she spent three years working for IBM, running an international exhibition program in Manhattan.
In 1993, Case started an independent consulting practice where she developed museum executive roundtables focused on problem solving, opportunity analysis, execution, leadership potential, financial stability, board, staff, and volunteer excellence. These learning and leadership meetings continue today, and Case considers them her most important professional legacy. Case retired in 2019 and lives with her husband, Will Lowe, in Washington DC